The C/EBPβ antagonist peptide lucicebtide (ST101) induces macrophage polarization toward a pro-inflammatory phenotype and enhances anti-tumor immune responses.

doi:10.3389/fimmu.2025.1522699

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Article

The C/EBPβ antagonist peptide lucicebtide (ST101) induces macrophage polarization toward a pro-inflammatory phenotype and enhances anti-tumor immune responses.

Frontiers in immunology - 1 Jan 2025

Scuoppo Claudio, Ramirez Rick, Leong Siok F, Koester Mark, Mattes Zachary F, Mendelson Karen, Diehl Julia, Abbate Franco, Gallagher Erin, Ghamsari Lila, Vainstein-Haras Abi, Merutka Gene, Kappel Barry J, Rotolo Jim A

Abstract excerpt

Immune-checkpoint inhibitors (ICIs) have shown unprecedented success in a subset of immunogenic tumors, however a host of patients with advanced solid tumors fail to respond well or at all to immunotherapy. Refractory tumors commonly display a tumor microenvironment (TME) rich in immunosuppressive macrophages (M2-like) that suppress adaptive immunity and promote tumor progression. The ability to reprogram...

Read the complete abstract on PubMed

Topics

Humans
Animals
CCAAT-Enhancer-Binding Protein-beta
Mice
Tumor Microenvironment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Macrophages

Tumor-Associated Macrophages

Macrophage Activation

Phenotype

Cell Line, Tumor

Female

Peptides

Immune Checkpoint Inhibitors

Lymphocyte Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 40103809
DOI: 10.3389/fimmu.2025.1522699
PMCID: PMC11913834

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