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Macrophage sensitivity to bexmarilimab-induced reprogramming is shaped by the tumor microenvironment

1 May 2025

Abstract excerpt

BACKGROUND: Tumor-associated macrophages (TAMs) adapt to the tumor microenvironment (TME), either aiding cancer eradication or promoting tumor growth and immune evasion. To manipulate TAMs therapeutically, a deep understanding of their interaction with the TME is essential. This study explores the responsiveness of TMEs to bexmarilimab, a macrophage reprogramming therapy showing clinical benefit in various solid...

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PMID: 40379271
DOI: 10.1136/jitc-2024-011292

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