Article

Quantifying ‘just-right’ APC inactivation for colorectal cancer initiation

2024-07-14

Abstract excerpt

Dysregulation of the tumour suppressor gene Adenomatous Polyposis Coli ( APC) is a canonical step in colorectal cancer development. Curiously, most colorectal tumours carry biallelic mutations that result in only partial loss of APC function, suggesting that a ‘just-right’ level of APC inactivation, and hence Wnt signalling, provides the optimal conditions for tumorigenesis. Mutational processes act variably acro...

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Literature Corpus work: 5f8100dd-651d-5564-a1b9-f122fb4c4544
DOI: 10.1101/2024.07.10.602868

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