Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mathematical model of colorectal cancer initiation.

Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2020

Paterson Chay, Clevers Hans, Bozic Ivana

Abstract excerpt

Quantifying evolutionary dynamics of cancer initiation and progression can provide insights into more effective strategies of early detection and treatment. Here we develop a mathematical model of colorectal cancer initiation through inactivation of two tumor suppressor genes and activation of one oncogene, accounting for the well-known path to colorectal cancer through loss of tumor suppressors APC and TP53 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, ras
Share to Models, Theoretical
Share to Mutation Rate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oncogenes

Share to Colonic Neoplasms

Share to Genes, APC

Share to Genes, p53

Share to Carcinogenesis

Source

Open in PubMed Open full text

Identifiers

PMID: 32788368
DOI: 10.1073/pnas.2003771117
PMCID: PMC7456111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mathematical model of colorectal cancer initiation.PMID 32788368Read ↗

Mathematical modeling the order of driver gene mutations in colorectal cancer.Semantic proximity Read ↗

Waiting times in a branching process model of colorectal cancer initiation.Semantic proximity Read ↗

Stochastic dynamics of cancer initiation.Semantic proximity Read ↗

Linear Model of Colon Cancer InitiationSemantic proximity Read ↗

Mathematical modeling of multiple pathways in colorectal carcinogenesis using dynamical systems with Kronecker structure.Semantic proximity Read ↗

Mathematical Modeling of Multiple Pathways in Colorectal Carcinogenesis using Dynamical Systems with Kronecker StructureSemantic proximity Read ↗

Multistage carcinogenesis and the incidence of colorectal cancerSemantic proximity Read ↗

Impacts of mutation accumulation and order on tumor initiation revealed by engineered murine colorectal cancer organoidsSemantic proximity Read ↗

Immunosuppressive niche engineering at the onset of human colorectal cancerSemantic proximity Read ↗

The Evolutionary Landscape of Colorectal Tumorigenesis: Recent Paradigms, Models, and Hypotheses.Semantic proximity Read ↗

New insights into the earliest stages of colorectal tumorigenesis.Semantic proximity Read ↗

Immunosuppressive niche engineering at the onset of human colorectal cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.