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STREAM-PRS: a multi-tool pipeline for streamlining polygenic risk score computation.

Genome medicine - 9 Oct 2025

Becelaere Sara, Abakkouy Yasmina, Jans Deborah Sarah, David Margaux, Vermeire Séverine, Cleynen Isabelle

Abstract excerpt

BACKGROUND: Polygenic risk scores (PRS) offer an elegant approach to estimating an individual's genetic predisposition to a given disease or trait. Numerous tools are available for PRS calculation, each applying different strategies to account for linkage disequilibrium and effect size shrinkage. No single tool is inherently superior. Therefore, multiple tools should be tested to identify the one that best suits...

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PMID: 41068909
DOI: 10.1186/s13073-025-01539-0
PMCID: PMC12512491

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