Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic mutations in neurodegeneration: An update.

Neurobiology of disease - 1 Oct 2020

Proukakis Christos

Abstract excerpt

Mosaicism, the presence of genomic differences between cells due to post-zygotic somatic mutations, is widespread in the human body, including within the brain. A role for this in neurodegenerative diseases has long been hypothesised, and technical developments are now allowing the question to be addressed in detail. The rapidly accumulating evidence is discussed in this review, with a focus on recent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Amyloid beta-Protein Precursor
Share to DNA Repeat Expansion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Huntington Disease

Share to Multiple System Atrophy

Share to Neurodegenerative Diseases

Share to Retroelements

Share to tau Proteins

Source

Identifiers

PMID: 32712267
DOI: 10.1016/j.nbd.2020.105021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic mutations in neurodegeneration: An update.PMID 32712267Read ↗

Review: Somatic mutations in neurodegeneration.Semantic proximity Read ↗

Brain somatic mutations in Alzheimer's disease: linking genetic mosaicism to neurodegeneration.Semantic proximity Read ↗

Genomic Mosaicism Formed by Somatic Variation in the Aging and Diseased Brain.Semantic proximity Read ↗

Somatic mutation, genomic variation, and neurological disease.Semantic proximity Read ↗

Brain Somatic Mutation in Aging and Alzheimer's Disease.Semantic proximity Read ↗

Somatic mosaicism in the diseased brainSemantic proximity Read ↗

Investigation of somatic mutations in human brains targeting genes associated with Parkinson’s diseaseSemantic proximity Read ↗

Somatic mosaicism: implications for disease and transmission genetics.Semantic proximity Read ↗

Genetic mosaicism in the human brain: from lineage tracing to neuropsychiatric disorders.Semantic proximity Read ↗

Somatic mutations in neurons during aging and neurodegeneration.Semantic proximity Read ↗

Somatic mutation: a cause of sporadic neurodegenerative diseases?Semantic proximity Read ↗

The role of germline and somatic nuclear and mitochondrial DNA variation in neurodegenerative disordersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.