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Article

On the identification of low allele frequency mosaic mutations in the brains of Alzheimer's disease patients.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2015

Sala Frigerio Carlo, Lau Pierre, Troakes Claire, Deramecourt Vincent, Gele Patrick, Van Loo Peter, Voet Thierry, De Strooper Bart

Abstract excerpt

INTRODUCTION: The cause of sporadic Alzheimer's disease (AD) remains unclear. Given the growing evidence that protein aggregates can spread in a "prion-like" fashion, we reasoned that a small population of brain cells producing such "prion-like" particles due to a postzygotic acquired mutation would be sufficient to trigger the disease. Deep DNA sequencing technology should in principle allow the detection of...

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Source

Identifiers

PMID: 25937274
DOI: 10.1016/j.jalz.2015.02.007

Genes

PSEN2
MAPT
PSEN1
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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