Article

A <i>de novo</i> paradigm for male infertility

2021-02-27

Abstract excerpt

<h4>Introduction</h4> De novo mutations (DNMs) are known to play a prominent role in sporadic disorders with reduced fitness 1 . We hypothesize that DNMs play an important role in male infertility and explain a significant fraction of the genetic causes of this understudied disorder. To test this hypothesis, we performed trio-based exome-sequencing in a unique cohort of 185 infertile males and their unaffected p...

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Literature Corpus work: 453e5fe6-c511-5ec3-84d7-ec27d5632686
DOI: 10.1101/2021.02.27.433155

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