Article

Hotspots of human mutation point to clonal expansions in spermatogonia

2025-01-05

Abstract excerpt

In renewing tissues, mutations conferring selective advantage may result in clonal expansions 1–4 . In contrast to somatic tissues, mutations driving clonal expansions in spermatogonia (CES) are also transmitted to the next generation. This results in an effective increase of de novo mutation rate for CES drivers 5–8 . CES was originally discovered through extreme recurrence of de novo mutations causing Apert...

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Literature Corpus work: 894bc9d2-c32f-5da1-8bb9-509ab46de2f7
DOI: 10.1101/2025.01.03.25319979

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