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Article

Polygenic Risk for Type 2 Diabetes in African Americans.

Diabetes - 1 Jun 2024

Irvin Marguerite R, Ge Tian, Patki Amit, Srinivasasainagendra Vinodh, Armstrong Nicole D, Davis Brittney, Jones Alana C, Perez Emma, Stalbow Lauren, Lebo Matthew, Kenny Eimear, Loos Ruth J F, Ng Maggie C Y, Smoller Jordan W, Meigs James B, Lange Leslie A, Karlson Elizabeth W, Limdi Nita A, Tiwari Hemant K

Abstract excerpt

African Americans (AAs) have been underrepresented in polygenic risk score (PRS) studies. Here, we integrated genome-wide data from multiple observational studies on type 2 diabetes (T2D), encompassing a total of 101,987 AAs, to train and optimize an AA-focused T2D PRS (PRSAA), using a Bayesian polygenic modeling method. We further tested the score in three independent studies with a total of 7,275 AAs and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38470993
DOI: 10.2337/db23-0232
PMCID: PMC11109789

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