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Article

Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance.

Cell - 13 Nov 2025

Culviner Peter H, Frey Abigail M, Liu Qingyun, Ha Dang Thi Minh, Thai Phan Vuong Khac, Thu Do Dang Anh, Quang Nguyen Le, Calderon Roger, Lecca Leonid, Caws Maxine, Dunstan Sarah J, Murray Megan B, Thuong Nguyen Thuy Thuong, Fortune Sarah M

Abstract excerpt

Mycobacterium tuberculosis (Mtb) has co-evolved with humans for thousands of years and is characterized by variation in virulence, transmissibility, and disease phenotypes. To identify bacterial contributors to phenotypic diversity, we developed new RNA sequencing (RNA-seq) and phylogenomic tools to capture hundreds of Mtb isolate transcriptomes, link transcriptional and genetic variation, and find associations...

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Share to Antigens, Bacterial
Share to Drug Resistance, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Bacterial

Share to Mycobacterium tuberculosis

Share to Transcription, Genetic

Share to Transcriptome

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Source

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Identifiers

PMID: 41033311
DOI: 10.1016/j.cell.2025.09.005
PMCID: PMC12624571

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