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Understanding Mycobacterium tuberculosis through its genomic diversity and evolution.

PLoS pathogens - 1 Feb 2025

Sweeney Mollie I, Carranza Carson E, Tobin David M

Abstract excerpt

Pathogen evolution and genomic diversity are shaped by specific host immune pressures and therapeutic interventions. Analysis of the extant genomes of circulating strains of Mycobacterium tuberculosis, a leading cause of infectious mortality that has co-evolved with humans for thousands of years, can provide new insights into host-pathogen interactions that underlie specific aspects of pathogenesis and onward...

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PMID: 40019877
DOI: 10.1371/journal.ppat.1012956
PMCID: PMC11870338

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