Transcriptional Profiling of Human Peripheral Blood Mononuclear Cells Identifies Diagnostic Biomarkers That Distinguish Active and Latent Tuberculosis

Abstract excerpt

Mycobacterium tuberculosis (M. tuberculosis) infection in humans can cause active disease or latent infection. However, the factors contributing to the maintenance of latent infection versus disease progression are poorly understood. In this study, we used a genome-wide RNA sequencing (RNA-seq) approach to identify host factors associated with M. tuberculosis infection status and a novel gene signature that can...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Diagnosis and treatment of tuberculosis
• Share to Mycobacterium research and diagnosis
• Share to Tuberculosis Research and Epidemiology