Article
LysG-driven transcriptional network rewiring underlies lineage-specific phenotypes in Mycobacterium tuberculosis.
Nature communications - 23 Mar 2026
Banaei-Esfahani Amir, Borrell Sonia, Trauner Andrej, Gygli Sebastian M, Rustad Tige R, Feldmann Julia, Gillet Ludovic C, Schubert Olga T, Beisel Christian, Sherman David R, Aebersold Ruedi, Gagneux Sebastien, Collins Ben C
Abstract excerpt
The Mycobacterium tuberculosis complex (MTBC) includes ten human-adapted lineages with varying geography and pathogenicity. Lineage 1 (L1) shows low virulence while Lineage 2 (L2) is hyper-virulent, more transmissible, and associated with drug-resistance. We performed comparative analyses integrating whole-genome sequencing with transcriptomic and proteomic profiling of L1 and L2 clinical strains under two in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.