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Evolution of <i>Mycobacterium tuberculosis</i> transcription regulation is associated with increased transmission and drug resistance

2025-05-01

Abstract excerpt

<h4>Summary</h4> Mycobacterium tuberculosis (Mtb) has co-evolved with humans for thousands of years causing variation in virulence, transmissibility, and disease phenotypes. To identify bacterial contributors to phenotypic diversity, we developed new RNA-seq and phylogenomic tools to capture hundreds of Mtb isolate transcriptomes, link transcriptional and genetic variation, and find associations between variants...

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Literature Corpus work
209bbf0b-0023-5d79-895f-f3b8122d2c8b
DOI
10.1101/2025.05.01.651750
Open publication

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Evolution of <i>Mycobacterium tuberculosis</i> transcription regulation is associated with increased transmission and drug resistanceDOI 10.1101/2025.05.01.651750
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