Article
Multiplexed Strain Phenotyping Defines Consequences of Genetic Diversity in Mycobacterium tuberculosis for Infection and Vaccination Outcomes.
mSystems - 28 Jun 2022
Carey Allison F, Wang Xin, Cicchetti Nico, Spaulding Caitlin N, Liu Qingyun, Hopkins Forrest, Brown Jessica, Sixsmith Jaimie, Sutiwisesak Rujapak, Behar Samuel M, Ioerger Thomas R, Fortune Sarah M
Abstract excerpt
There is growing evidence that genetic diversity in Mycobacterium tuberculosis, the causative agent of tuberculosis, contributes to the outcomes of infection and public health interventions, such as vaccination. Epidemiological studies suggest that among the phylogeographic lineages of M. tuberculosis, strains belonging to a sublineage of Lineage 2 (mL2) are associated with concerning clinical features, including...
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