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Genetic Diversity in Mycobacterium tuberculosis Clinical Isolates and Resulting Outcomes of Tuberculosis Infection and Disease.

Annual review of genetics - 23 Nov 2020

Peters Julian S, Ismail Nabila, Dippenaar Anzaan, Ma Shuyi, Sherman David R, Warren Robin M, Kana Bavesh D

Abstract excerpt

Tuberculosis claims more human lives than any other bacterial infectious disease and represents a clear and present danger to global health as new tools for vaccination, treatment, and interruption of transmission have been slow to emerge. Additionally, tuberculosis presents with notable clinical heterogeneity, which complicates diagnosis, treatment, and the establishment of nonrelapsing cure. How this...

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PMID: 32926793
DOI: 10.1146/annurev-genet-022820-085940

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