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Article

A Phenome-Wide Comorbidity Atlas of Age-Related Hearing Loss, Speech-in-Noise Deficits, and Tinnitus: Distinguishing Causal Signals from Correlation.

Journal of the Association for Research in Otolaryngology : JARO - 1 Dec 2025

Bhatt Ishan Sunilkumar, Tucker Denise, Britton Mitra, Hoffa Ashely, Pate Brandon J, Dias Raquel, Garay Juan Antonio Raygoza

Abstract excerpt

PURPOSE: The present study employed a data-driven and hypothesis-free approach to identify comorbidities associated with age-related hearing loss (ARHL), speech-in-noise (SIN) deficits, and tinnitus. METHODS: The study performed phenome-wide co-occurrence association analyses using the UK Biobank cohort to identify comorbidities associated with ARHL (N = 429,318), SIN deficits (N = 437,155), tinnitus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41023319
DOI: 10.1007/s10162-025-01008-w
PMCID: PMC12698885

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