Article
Gene burden analysis identifies genes associated with increased risk and severity of adult-onset hearing loss in a diverse hospital-based cohort.
PLoS genetics - 1 Jan 2023
Hui Daniel, Mehrabi Shadi, Quimby Alexandra E, Chen Tingfang, Chen Sixing, Park Joseph, Li Binglan, Ruckenstein Michael J, Rader Daniel J, Ritchie Marylyn D, Brant Jason A, Epstein Douglas J, Mathieson Iain
Abstract excerpt
Loss or absence of hearing is common at both extremes of human lifespan, in the forms of congenital deafness and age-related hearing loss. While these are often studied separately, there is increasing evidence that their genetic basis is at least partially overlapping. In particular, both common and rare variants in genes associated with monogenic forms of hearing loss also contribute to the more polygenic basis...
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