Article

Genome-wide association study meta-analysis brings monogenic hearing loss genes into the polygenic realm

2025-03-03

Abstract excerpt

<h4>Background</h4> Disabling age-related and noise-induced sensorineural hearing loss (SNHL) affects 5% of the global population and is associated with isolation, depression, cognitive decline, and dementia. SNHL is strongly heritable with a polygenic signature of common genetic variants conferring small risks individually, thus requiring very large studies to achieve statistical power in genome-wide association...

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Literature Corpus work: cefeb4d1-13a9-5445-b30e-60cd05f218f5
DOI: 10.1101/2025.02.28.25323059

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