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Multi-ancestry GWAS of age-related hearing loss identifies 140 loci and key cellular mechanisms.

Nature communications - 21 Feb 2026

Shi Lulu, He Haibin, Li Junpeng, Gai Kai, Li Wenjian, Zhao Yu, Yuan Huijun, Wu Yang

Abstract excerpt

Age-related hearing loss is a prevalent and growing public health issue among the elderly. Here, we perform a multi-ancestry genome-wide association study comprising 456,613 cases and 1,053,834 controls, identifying 140 independent loci associated with age-related hearing loss, including 44 novel signals. We further fine-map 9 likely causal missense variants for age-related hearing loss and provide evidence of...

Topics

Genome-Wide Association Study
Humans
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide
Presbycusis
DNA Methylation
Aging
Hearing Loss
Ear, Inner

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open in PubMed Open full text

Identifiers

PMID: 41723152
DOI: 10.1038/s41467-026-69894-z
PMCID: PMC13172361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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