Novel Risk Loci in Tinnitus and Causal Inference With Neuropsychiatric Disorders Among Adults of European Ancestry.

doi:10.1001/jamaoto.2020.2920

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Article

Novel Risk Loci in Tinnitus and Causal Inference With Neuropsychiatric Disorders Among Adults of European Ancestry.

JAMA otolaryngology-- head & neck surgery - 1 Nov 2020

Clifford Royce E, Maihofer Adam X, Stein Murray B, Ryan Allen F, Nievergelt Caroline M

Abstract excerpt

Importance: Tinnitus affects at least 16 million US adults, but its pathophysiology is complicated, and treatment options remain limited. A heritable component has been identified in family and twin studies; however, no large-scale genome-wide association studies (GWAS) have been accomplished. Objective: To identify genetic risk loci associated with tinnitus, determine genetic correlations, and infer possible...

Topics

Adult
Aged
Europe
Female
Genetic Loci
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Incidence
Male
Middle Aged
Phenotype
Psychotic Disorders
Tinnitus
United States

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Identifiers

PMID: 32970095
DOI: 10.1001/jamaoto.2020.2920
PMCID: PMC7516809

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