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Article

A multi-ethnic polygenic risk score for chronic kidney disease is associated with increased risk of hypertension in African American individuals.

BMC nephrology - 26 Sept 2025

Kakar Aastha, Litkowski Elizabeth M, Scadden Ashley W, Anwar Mohammad Y, Konigsberg Iain R, Stanislawski Maggie A, DuPre Natalie C, Mitra Riten, Baumgartner Richard, Raffield Laura M, Lange Ethan M, Lange Leslie A, Taylor Kira C

Abstract excerpt

BACKGROUND: Hypertension (HT) and chronic kidney diseases (CKD) are complex conditions having both genetic and environmental contributions, disproportionately affecting African American (AA) individuals. Recent evidence is contradictory regarding the directionality of the relationship between the two conditions. This study investigates the relationship between CKD and blood pressure (BP)-related traits with CKD...

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Source

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Identifiers

PMID: 41013308
DOI: 10.1186/s12882-025-04425-4
PMCID: PMC12465664

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DBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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