A methylation risk score for chronic kidney disease: a HyperGEN study.

doi:10.1038/s41598-024-68470-z

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Article

A methylation risk score for chronic kidney disease: a HyperGEN study.

Scientific reports - 1 Aug 2024

Jones Alana C, Patki Amit, Srinivasasainagendra Vinodh, Hidalgo Bertha A, Tiwari Hemant K, Limdi Nita A, Armstrong Nicole D, Chaudhary Ninad S, Minniefield Bré, Absher Devin, Arnett Donna K, Lange Leslie A, Lange Ethan M, Young Bessie A, Diamantidis Clarissa J, Rich Stephen S, Mychaleckyj Josyf C, Rotter Jerome I, Taylor Kent D, Kramer Holly J, Tracy Russell P, Durda Peter, Kasela Silva, Lappalinen Tuuli, Liu Yongmei, Johnson W Craig, Van Den Berg David J, Franceschini Nora, Liu Simin, Mouton Charles P, Bhatti Parveen, Horvath Steve, Whitsel Eric A, Irvin Marguerite R

Abstract excerpt

Chronic kidney disease (CKD) impacts about 1 in 7 adults in the United States, but African Americans (AAs) carry a disproportionately higher burden of disease. Epigenetic modifications, such as DNA methylation at cytosine-phosphate-guanine (CpG) sites, have been linked to kidney function and may have clinical utility in predicting the risk of CKD. Given the dynamic relationship between the epigenome, environment,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39085340
DOI: 10.1038/s41598-024-68470-z
PMCID: PMC11291488

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