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Article

Genome-Wide Aggregated Trans-Effects Analysis Implicates Deficient Type III Interferon Signaling as a Key Cause of Inflammatory Bowel Disease.

Inflammatory bowel diseases - 1 Nov 2025

McKeigue Paul M, Iakovliev Andrii, Erabadda Buddhiprabha, Colhoun Helen M, Spiliopoulou Athina

Abstract excerpt

BACKGROUND: Genome-wide association studies of inflammatory bowel disease have identified hundreds of common genetic variants that are associated with inflammatory bowel disease, but few promising therapeutic targets. The "omnigenic" sparse effector hypothesis postulates that the polygenic effects of common SNPs on a typical complex trait are mediated by trans-effects that coalesce on the expression of a sparse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40996888
DOI: 10.1093/ibd/izaf214
PMCID: PMC12638058

Genes

HERC5
IFI44
IFI44L
IFNL1
MX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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