Article
Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease.
Nature communications - 18 Feb 2021
Hu Shixian, Uniken Venema Werna T, Westra Harm-Jan, Vich Vila Arnau, Barbieri Ruggero, Voskuil Michiel D, Blokzijl Tjasso, Jansen Bernadien H, Li Yanni, Daly Mark J, Xavier Ramnik J, Dijkstra Gerard, Festen Eleonora A, Weersma Rinse K
Abstract excerpt
More than 240 genetic risk loci have been associated with inflammatory bowel disease (IBD), but little is known about how they contribute to disease development in involved tissue. Here, we hypothesized that host genetic variation affects gene expression in an inflammation-dependent way, and investigated 299 snap-frozen intestinal biopsies from inflamed and non-inflamed mucosa from 171 IBD patients....
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