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Article

Genome-wide aggregated trans-effects on risk of type 1 diabetes: A test of the "omnigenic" sparse effector hypothesis of complex trait genetics.

American journal of human genetics - 1 Jun 2023

Iakovliev Andrii, McGurnaghan Stuart J, Hayward Caroline, Colombo Marco, Lipschutz Debby, Spiliopoulou Athina, Colhoun Helen M, McKeigue Paul M

Abstract excerpt

The "omnigenic" hypothesis postulates that the polygenic effects of common SNPs on a typical complex trait are mediated through trans-effects on expression of a relatively sparse set of effector ("core") genes. We tested this hypothesis in a study of 4,964 cases of type 1 diabetes (T1D) and 7,497 controls by using summary statistics to calculate aggregated (excluding the HLA region) trans-scores for gene...

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Share to Diabetes and associated disorders
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diet, Metabolism, and Disease

Share to Genetic Predisposition to Disease

Share to Multifactorial Inheritance

Share to Pancreatic function and diabetes

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

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Identifiers

PMID: 37164005
DOI: 10.1016/j.ajhg.2023.04.003
PMCID: PMC10257008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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