When neighbors play a role: A systems-level analysis of protein interactions conditioning cancer driver mutation effects.

Abstract excerpt

Cancer is driven by the accumulation of somatic mutations, including driver mutations that confer a selective advantage to cancer cells. Driver proteins operate within complex interaction networks, and their activity is conditioned by neighbor proteins. Understanding the interplay between driver mutations and the expression of their neighbor proteins can provide insights into cancer biology and potential...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gene Expression Regulation, Neoplastic
• Share to Mutation