Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Circuits of cancer drivers revealed by convergent misregulation of transcription factor targets across tumor types.

Genome medicine - 20 Jan 2016

Gonzalez-Perez Abel

Abstract excerpt

BACKGROUND: Large tumor genome sequencing projects have now uncovered a few hundred genes involved in the onset of tumorigenesis, or drivers, in some two dozen malignancies. One of the main challenges emerging from this catalog of drivers is how to make sense of their heterogeneity in most cancer types. This is key not only to understand how carcinogenesis appears and develops in these malignancies to be able to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Computational Biology
Share to Gene Expression Profiling

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Gene Regulatory Networks

Share to Mutation

Share to Neoplasms

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 26792175
DOI: 10.1186/s13073-015-0260-1
PMCID: PMC4719577

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Circuits of cancer drivers revealed by convergent misregulation of transcription factor targets across tumor types.PMID 26792175Read ↗

Pan-Cancer Driver Mutation Signatures Define a Molecular Taxonomy of TumorsSemantic proximity Read ↗

Understanding oncogenicity of cancer driver genes and mutations in the cancer genomics era.Semantic proximity Read ↗

Comprehensive identification of mutational cancer driver genes across 12 tumor types.Semantic proximity Read ↗

The whole-genome panorama of cancer driversSemantic proximity Read ↗

Deciphering oncogenic drivers: from single genes to integrated pathways.Semantic proximity Read ↗

Cancer type-specific variation in patterns of driver alterations across 50,000 tumors.Semantic proximity Read ↗

Mutational Landscape of Cancer-Driver Genes Across Human CancersSemantic proximity Read ↗

Interpreting pathways to discover cancer driver genes with Moonlight.Semantic proximity Read ↗

Mutational landscape of cancer-driver genes across human cancers.Semantic proximity Read ↗

Emerging landscape of oncogenic signatures across human cancers.Semantic proximity Read ↗

Integration of multiple networks and pathways identifies cancer driver genes in pan-cancer analysisSemantic proximity Read ↗

Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.