Article
Identification of cancer driver genes based on nucleotide context.
Nature genetics - 1 Feb 2020
Dietlein Felix, Weghorn Donate, Taylor-Weiner Amaro, Richters André, Reardon Brendan, Liu David, Lander Eric S, Van Allen Eliezer M, Sunyaev Shamil R
Abstract excerpt
Cancer genomes contain large numbers of somatic mutations but few of these mutations drive tumor development. Current approaches either identify driver genes on the basis of mutational recurrence or approximate the functional consequences of nonsynonymous mutations by using bioinformatic scores. Passenger mutations are enriched in characteristic nucleotide contexts, whereas driver mutations occur in functional...
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