Article

When neighbours play a role: a systems-level analysis of protein interactions conditioning cancer driver mutation effects

2025-01-22

Abstract excerpt

<h4>Background</h4> Cancer is driven by the accumulation of somatic mutations, including driver mutations that confer a selective advantage to cancer cells. Driver proteins operate within complex interaction networks, and their activity is conditioned by neighbour proteins. Understanding the interplay between driver mutations and the expression of their neighbour proteins can provide insights into cancer biology...

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Literature Corpus work: d6559735-06a2-5a02-87dc-4576b066faf5
DOI: 10.1101/2025.01.18.633728

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