Article
Interpreting pathways to discover cancer driver genes with Moonlight.
Nature communications - 3 Jan 2020
Colaprico Antonio, Olsen Catharina, Bailey Matthew H, Odom Gabriel J, Terkelsen Thilde, Silva Tiago C, Olsen André V, Cantini Laura, Zinovyev Andrei, Barillot Emmanuel, Noushmehr Houtan, Bertoli Gloria, Castiglioni Isabella, Cava Claudia, Bontempi Gianluca, Chen Xi Steven, Papaleo Elena
Abstract excerpt
Cancer driver gene alterations influence cancer development, occurring in oncogenes, tumor suppressors, and dual role genes. Discovering dual role cancer genes is difficult because of their elusive context-dependent behavior. We define oncogenic mediators as genes controlling biological processes. With them, we classify cancer driver genes, unveiling their roles in cancer mechanisms. To this end, we present...
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