Article
Decreased prepulse inhibition and increased sensitivity to muscarinic, but not dopaminergic drugs in M5 muscarinic acetylcholine receptor knockout mice.
Psychopharmacology - 1 May 2007
Thomsen Morgane, Wörtwein Gitta, Fink-Jensen Anders, Woldbye David P D, Wess Jürgen, Caine S Barak
Abstract excerpt
RATIONALE: Schizophrenic patients show decreased measures of sensorimotor gating, such as prepulse inhibition of startle (PPI). In preclinical models, these measures may be used to predict antipsychotic activity. While current antipsychotic drugs act largely at dopamine receptors, the muscarinic acetylcholine receptors offer promising novel pharmacotherapy targets. Of these, the M(5) receptor gene was recently...
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