Article
Behavioral and neurochemical phenotyping of Homer1 mutant mice: possible relevance to schizophrenia.
Genes, brain, and behavior - 1 Jul 2005
Szumlinski K K, Lominac K D, Kleschen M J, Oleson E B, Dehoff M H, Schwarz M K, Schwartz M K, Seeburg P H, Seeberg P H, Worley P F, Kalivas P W
Abstract excerpt
Homer proteins are involved in the functional assembly of postsynaptic density proteins at glutamatergic synapses and are implicated in learning, memory and drug addiction. Here, we report that Homer1-knockout (Homer1-KO) mice exhibit behavioral and neurochemical abnormalities that are consistent with the animal models of schizophrenia. Relative to wild-type mice, Homer1-KO mice exhibited deficits in radial arm...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.