Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Decreased amphetamine-induced locomotion and improved latent inhibition in mice mutant for the M5 muscarinic receptor gene found in the human 15q schizophrenia region.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Dec 2004

Wang Haoran, Ng Karen, Hayes David, Gao Xiangrong, Forster Gina, Blaha Charles, Yeomans John

Abstract excerpt

M5 muscarinic receptors are coexpressed with D2 dopamine receptors in the ventral tegmentum and striatum, and are important for reward in rodents. Previously, we reported that disruption of the M5 receptor gene in mice reduced dopamine release in the nucleus accumbens. In this study, we establish...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acoustic Stimulation
Share to Amphetamine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Central Nervous System Stimulants

Share to Inhibition, Psychological

Share to Locomotion

Share to Pain Measurement

Share to Psychomotor Performance

Share to Reflex, Startle

Source

Identifiers

PMID: 15213703
DOI: 10.1038/sj.npp.1300502

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15213703-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Decreased amphetamine-induced locomotion and improved latent inhibition in mice mutant for the M5 muscarinic receptor gene found in the human 15q schizophrenia region.PMID 15213703Read ↗

Genetic Disruption of Arc/Arg3.1 in Mice Causes Alterations in Dopamine and Neurobehavioral Phenotypes Related to Schizophrenia.Semantic proximity Read ↗

Sex-dependent Schizophrenia and Drug Reward Behavioral Phenotypes in Metabotropic Glutamate 5 Receptor Heterozygous and Homozygous Mice.Semantic proximity Read ↗

Decreased prepulse inhibition and increased sensitivity to muscarinic, but not dopaminergic drugs in M5 muscarinic acetylcholine receptor knockout mice.Semantic proximity Read ↗

Subchronic amphetamine decreases hyperactivity, anti-social behaviour and anhedonia in dopamine transporter knockout rats: role of prefrontal glutamateSemantic proximity Read ↗

Assessment of behaviors modeling aspects of schizophrenia in Csmd1 mutant mice.Semantic proximity Read ↗

Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons.Semantic proximity Read ↗

Altered motor activity, exploration and anxiety in heterozygous neuregulin 1 mutant mice: implications for understanding schizophrenia.Semantic proximity Read ↗

Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine.Semantic proximity Read ↗

The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia.Semantic proximity Read ↗

Alterations in amphetamine-stimulated dopamine overflow due to the Nurr1-null heterozygous genotype and postweaning isolation.Semantic proximity Read ↗

Methamphetamine-associated psychosis.Semantic proximity Read ↗

The Habenular Receptor GPR151 Regulates Addiction Vulnerability Across Drug ClassesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.