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Article

Deciphering the role of APOE in cerebral amyloid angiopathy: from genetic insights to therapeutic horizons.

Annals of medicine - 1 Dec 2025

Hu Hantian, Wan Siqi, Hu Yuetao, Wang Qi, Li Hanyu, Zhang Nan

Abstract excerpt

Cerebral amyloid angiopathy (CAA), characterized by the deposition of amyloid-β (Aβ) peptides in the walls of medium and small vessels of the brain and leptomeninges, is a major cause of lobar hemorrhage in elderly individuals. Among the genetic risk factors for CAA that continue to be recognized, the apolipoprotein E (APOE) gene is the most significant and prevalent, as its variants have been implicated in more...

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Source

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Identifiers

PMID: 39745195
DOI: 10.1080/07853890.2024.2445194
PMCID: PMC11703089

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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