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Apolipoprotein E genotype-dependent accumulation of amyloid β in APP-knock-in mouse model of Alzheimer's disease.

Biochemical and biophysical research communications - 26 Nov 2023

Takebayashi Yoshiko, Yamazaki Yu, Yamada Hidetada, Yazawa Kyosuke, Nakamori Masahiro, Kurashige Takashi, Morino Hiroyuki, Takahashi Tetsuya, Sotomaru Yusuke, Maruyama Hirofumi

Abstract excerpt

Apolipoprotein E4 (APOE4), the strongest risk factor for late-onset Alzheimer's disease (AD), has been revealed to cause greater accumulation of extracellular amyloid β (Aβ) aggregates than does APOE3 in traditional transgenic mouse models of AD. However, concerns that the overexpression paradigm might have affected the phenotype remain. Amyloid precursor protein (APP)-knock-in (KI) mice, incorporating APP...

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PMID: 37857162
DOI: 10.1016/j.bbrc.2023.10.038

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