Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model

1 Jun 2000

Abstract excerpt

The epsilon4 allele of apolipoprotein E (ApoE) is an important genetic risk factor for Alzheimer's disease (AD). Increasing evidence suggests that this association may be linked to the ability of ApoE to interact with the amyloid-beta (Abeta) peptide and influence its concentration and structure. To determine the effect of ApoE on Abeta and other AD pathology in vivo, we used APPsw transgenic mice and ApoE...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Cholinesterase and Neurodegenerative Diseases
Share to Dementia and Cognitive Impairment Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10852539
DOI: 10.1002/1531-8249(200006)47:6<739::aid-ana6>3.0.co;2-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease modelPMID 10852539Read ↗

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease.Semantic proximity Read ↗

Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse modelsSemantic proximity Read ↗

Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models.Semantic proximity Read ↗

Comparison of the ApoE allelic variants in the formation of intracerebral Aβ deposits.Semantic proximity Read ↗

Alzheimer beta amyloid deposition enhanced by apoE epsilon4 gene precedes neurofibrillary pathology in the frontal association cortex of nondemented senior subjects.Semantic proximity Read ↗

Apolipoprotein E and beta-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein E genotype dependent.Semantic proximity Read ↗

Neprilysin Deficiency Alters the Neuropathological and Behavioral Phenotype in the 5XFAD Mouse Model of Alzheimer's DiseaseSemantic proximity Read ↗

A humanized Aβ mouse model reveals E4-dependent cognitive impairments, microglial activation, and cerebrovascular dysfunctionSemantic proximity Read ↗

Role of apoe/Abeta interactions in the pathogenesis of Alzheimer's disease and cerebral amyloid angiopathy.Semantic proximity Read ↗

C/EBPβ/AEP Signaling Activated by ApoE4 and 27-Hydroxycholesterol in Macrophages Mediates Cerebral Amyloid Angiopathies in Alzheimer’s DiseaseSemantic proximity Read ↗

Deciphering the role of APOE in cerebral amyloid angiopathy: from genetic insights to therapeutic horizons.Semantic proximity Read ↗

APOE in the normal brainSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.