Back to search

Article

Functional non-coding SNPs in human endothelial cells fine-map vascular trait associations

2021-08-03

Abstract excerpt

Functional consequences of genetic variation in the non-coding human genome are difficult to ascertain despite demonstrated associations to common, complex disease traits. To elucidate properties of functional non-coding SNPs with effects in human endothelial cells (EC), we utilized molecular Quantitative Trait Locus (molQTL) analysis for transcription factor binding, chromatin accessibility, and H3K27 acetylation...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c8364f01-f8fd-52bf-85fd-329ef3ef3819
DOI
10.1101/2021.08.03.454513
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Functional non-coding SNPs in human endothelial cells fine-map vascular trait associationsDOI 10.1101/2021.08.03.454513
Functional noncoding SNPs in human endothelial cells fine-map vascular trait associations.Semantic proximity
Systems Genetics in Human Endothelial Cells Identifies Non-coding Variants Modifying Enhancers, Expression, and Complex Disease Traits.Semantic proximity
High-resolution regulatory maps connect cardiovascular risk variants to disease related pathwaysSemantic proximity
Dissecting the Cellular Genetics of Cardiovascular Disease Through Endothelial and Immune Compartments ProfilingSemantic proximity
Epigenomic landscape of single vascular cells reflects developmental origin and disease risk loci.Semantic proximity
A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression.Semantic proximity
Regulatory Genomics of Preeclampsia-Specific Risk Variants Highlights Immune and Endothelial MechanismsSemantic proximity
A genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamicsSemantic proximity
Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells.Semantic proximity
Analysis of putative cis-regulatory elements regulating blood pressure variationSemantic proximity
GEM-Finder: dissecting GWAS variants via long-range interacting cis-regulatory elements with differentiation-specific genesSemantic proximity
Multimodal atlas of human atherosclerosis links granular vascular cell states to coronary artery disease riskSemantic proximity
Select a neighboring publication to make it the new centre.