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Microcin MccI47 selectively inhibits enteric bacteria and reduces carbapenem-resistant <i>Klebsiella pneumoniae</i> colonization <i>in vivo</i> when administered <i>via</i> an engineered live biotherapeutic

2021-12-19

Abstract excerpt

<h4>Background</h4> The gastrointestinal (GI) tract is the reservoir for multidrug-resistant (MDR) pathogens, specifically carbapenem-resistant (CR) Klebsiella pneumoniae and other Enterobacteriaceae , which often lead to the spread of antimicrobial resistance genes, severe extraintestinal infections, and lethal outcomes. Selective GI decolonization has been proposed as a new strategy for preventing transmissio...

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Literature Corpus work
d6c5067a-a132-58b4-a83d-87887e46fdae
DOI
10.1101/2021.12.17.473159
Open publication

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Microcin MccI47 selectively inhibits enteric bacteria and reduces carbapenem-resistant <i>Klebsiella pneumoniae</i> colonization <i>in vivo</i> when administered <i>via</i> an engineered live biotherapeuticDOI 10.1101/2021.12.17.473159
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