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Article

Streamlining genomes: toward the generation of simplified and stabilized microbial systems.

Current opinion in biotechnology - 1 Oct 2012

Leprince Audrey, van Passel Mark W J, dos Santos Vitor A P Martins

Abstract excerpt

At the junction between systems and synthetic biology, genome streamlining provides a solid foundation both for increased understanding of cellular circuitry, and for the tailoring of microbial chassis towards innovative biotechnological applications. Iterative genomic deletions (targeted and random) helps to generate simplified, stabilized and predictable genomes, whereas multiplexing genome engineering reveals...

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PMID: 22651991
DOI: 10.1016/j.copbio.2012.05.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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