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Meiotic Chromosome Structure, the Synaptonemal Complex, and Infertility.

Annual review of genomics and human genetics - 25 Aug 2023

Adams Ian R, Davies Owen R

Abstract excerpt

In meiosis, homologous chromosome synapsis is mediated by a supramolecular protein structure, the synaptonemal complex (SC), that assembles between homologous chromosome axes. The mammalian SC comprises at least eight largely coiled-coil proteins that interact and self-assemble to generate a long, zipper-like structure that holds homologous chromosomes in close proximity and promotes the formation of genetic...

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PMID: 37159901
DOI: 10.1146/annurev-genom-110122-090239

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