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Article

A novel mouse synaptonemal complex protein is essential for loading of central element proteins, recombination, and fertility.

PLoS genetics - 1 May 2011

Schramm Sabine, Fraune Johanna, Naumann Ronald, Hernandez-Hernandez Abrahan, Höög Christer, Cooke Howard J, Alsheimer Manfred, Benavente Ricardo

Abstract excerpt

The synaptonemal complex (SC) is a proteinaceous, meiosis-specific structure that is highly conserved in evolution. During meiosis, the SC mediates synapsis of homologous chromosomes. It is essential for proper recombination and segregation of homologous chromosomes, and therefore for genome haploidization. Mutations in human SC genes can cause infertility. In order to gain a better understanding of the process...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 21637789
DOI: 10.1371/journal.pgen.1002088
PMCID: PMC3102746

Genes

MLH1
SYCP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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