Genetics of lifespan in C. elegans: molecular diversity, physiological complexity, mechanistic simplicity.

doi:10.1016/s0168-9525(01)02523-9

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Article

Genetics of lifespan in C. elegans: molecular diversity, physiological complexity, mechanistic simplicity.

Trends in genetics : TIG - 1 Dec 2001

Hekimi S, Burgess J, Bussière F, Meng Y, Bénard C

Abstract excerpt

The nematode Caenorhabditis elegans is used as a model system for the study of aging. Several mutant strains that have an increased lifespan have been isolated and characterized genetically and molecularly. Molecular analysis reveals that diverse types of gene products can affect worm lifespan, including proteins active in signal transduction, transcription and silencing factors, mitochondrial enzymes, and at...

Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
DNA Damage
DNA Repair
Gene Silencing
Genetic Variation
Longevity
Models, Biological
Mutation
Signal Transduction
Transcription, Genetic

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Identifiers

PMID: 11718925
DOI: 10.1016/s0168-9525(01)02523-9

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