Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans.

doi:10.1371/journal.pgen.1000361

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans.

PLoS genetics - 1 Feb 2009

Van Raamsdonk Jeremy M, Hekimi Siegfried

Abstract excerpt

The oxidative stress theory of aging postulates that aging results from the accumulation of molecular damage caused by reactive oxygen species (ROS) generated during normal metabolism. Superoxide dismutases (SODs) counteract this process by detoxifying superoxide. It has previously been shown that elimination of either cytoplasmic or mitochondrial SOD in yeast, flies, and mice results in decreased lifespan. In...

Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Genes, Helminth
Longevity
Mitochondria
Osmotic Pressure
Oxidative Stress
Oxygen Consumption
Phenotype
RNA, Messenger
Sequence Deletion
Superoxide Dismutase

Source

Open in PubMed Open full text

Identifiers

PMID: 19197346
DOI: 10.1371/journal.pgen.1000361
PMCID: PMC2628729

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics