Article
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
Nature genetics - 1 Dec 2013
Lambert J C, Ibrahim-Verbaas C A, Harold D, Naj A C, Sims R, Bellenguez C, DeStafano A L, Bis J C, Beecham G W, Grenier-Boley B, Russo G, Thorton-Wells T A, Jones N, Smith A V, Chouraki V, Thomas C, Ikram M A, Zelenika D, Vardarajan B N, Kamatani Y, Lin C F, Gerrish A, Schmidt H, Kunkle B, Dunstan M L, Ruiz A, Bihoreau M T, Choi S H, Reitz C, Pasquier F, Cruchaga C, Craig D, Amin N, Berr C, Lopez O L, De Jager P L, Deramecourt V, Johnston J A, Evans D, Lovestone S, Letenneur L, Morón F J, Rubinsztein D C, Eiriksdottir G, Sleegers K, Goate A M, Fiévet N, Huentelman M W, Gill M, Brown K, Kamboh M I, Keller L, Barberger-Gateau P, McGuiness B, Larson E B, Green R, Myers A J, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, St George-Hyslop P, Clarimon J, Lleo A, Bayer A, Tsuang D W, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Sanchez-Garcia F, Fox N C, Hardy J, Deniz Naranjo M C, Bosco P, Clarke R, Brayne C, Galimberti D, Mancuso M, Matthews F, Moebus S, Mecocci P, Del Zompo M, Maier W, Hampel H, Pilotto A, Bullido M, Panza F, Caffarra P, Nacmias B, Gilbert J R, Mayhaus M, Lannefelt L, Hakonarson H, Pichler S, Carrasquillo M M, Ingelsson M, Beekly D, Alvarez V, Zou F, Valladares O, Younkin S G, Coto E, Hamilton-Nelson K L, Gu W, Razquin C, Pastor P, Mateo I, Owen M J, Faber K M, Jonsson P V, Combarros O, O'Donovan M C, Cantwell L B, Soininen H, Blacker D, Mead S, Mosley T H, Bennett D A, Harris T B, Fratiglioni L, Holmes C, de Bruijn R F, Passmore P, Montine T J, Bettens K, Rotter J I, Brice A, Morgan K, Foroud T M, Kukull W A, Hannequin D, Powell J F, Nalls M A, Ritchie K, Lunetta K L, Kauwe J S, Boerwinkle E, Riemenschneider M, Boada M, Hiltuenen M, Martin E R, Schmidt R, Rujescu D, Wang L S, Dartigues J F, Mayeux R, Tzourio C, Hofman A, Nöthen M M, Graff C, Psaty B M, Jones L, Haines J L, Holmans P A, Lathrop M, Pericak-Vance M A, Launer L J, Farrer L A, van Duijn C M, Van Broeckhoven C, Moskvina V, Seshadri S, Williams J, Schellenberg G D, Amouyel P
Abstract excerpt
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4...
