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Article

Shared genetic architecture between Alzheimer's disease and brain morphology.

Alzheimer's research & therapy - 11 Jun 2026

Wu Xiao, Shadrin Alexey, Blokland Gabriëlla A M, Guloksuz Sinan, Andreassen Ole A, Linden David E J, van der Meer Dennis

Abstract excerpt

BACKGROUND: A hallmark of Late-onset Alzheimer's disease (LOAD) is brain tissue atrophy across multiple cortical and subcortical regions. However, studies report no significant genetic correlation between LOAD and brain morphology, indicating that the genetic drivers of neurodegeneration are complex. Resolving this shared genetic architecture is key to uncovering the biological mechanisms linking brain morphology...

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PMID: 42271432
DOI: 10.1186/s13195-026-02105-5
PMCID: PMC13483600

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