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Article

Pp1-87B/PPP1CC-JNK axis integrates apoptosis and ferroptosis-like cell death to regulate cell competition and tumorigenesis

1 Sept 2025

Abstract excerpt

Cell competition, an evolutionarily conserved quality control mechanism, selectively removes unfit or pre-malignant cells via cell-cell interactions. Through a genetic screen in Drosophila, we identify the phosphatase Pp1-87B as an essential regulator of JNK signaling crucial for eliminating scrib-deficient precancerous cells during tumor-suppressive cell competition. Mechanistically, impaired Pp1-87B activates...

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PMID: 40906558
DOI: 10.1016/j.celrep.2025.116240

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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