Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of SPTBN1 Suppresses Autophagy Via SETD7-mediated YAP Methylation in Hepatocellular Carcinoma Initiation and Development

1 Nov 2021

Abstract excerpt

BACKGROUND & AIMS: Loss of Spectrin beta, non-erythrocytic 1 (SPTBN1) plays an important role in the carcinogenesis of hepatocellular carcinoma (HCC); however, the mechanisms underlying its involvement remain poorly understood. Defects in autophagy contribute to hepatic tumor formation. Hence, in this study, we explored the role and mechanism of SPTBN1 in the autophagy of hepatic stem cells (HSCs) and HCC cells....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Epigenetics and DNA Methylation
Share to Hippo pathway signaling and YAP/TAZ

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34737104
DOI: 10.1016/j.jcmgh.2021.10.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of SPTBN1 Suppresses Autophagy Via SETD7-mediated YAP Methylation in Hepatocellular Carcinoma Initiation and DevelopmentPMID 34737104Read ↗

Transcriptional regulation of STAT3 by SPTBN1 and SMAD3 in HCC through cAMP-response element-binding proteins ATF3 and CREB2Semantic proximity Read ↗

Analysis of Genomes and Transcriptomes of Hepatocellular Carcinomas Identifies Mutations and Gene Expression Changes in the Transforming Growth Factor-β Pathway.Semantic proximity Read ↗

Emerging role of Hpo signaling and YAP in hepatocellular carcinomaSemantic proximity Read ↗

YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor RegressionSemantic proximity Read ↗

RIPPLY1 suppresses cancer cell stemness via targeting TBX19 in CTNNB1 -mutated hepatocellular carcinoma.Semantic proximity Read ↗

Oncogenic Determination of a Broad Spectrum of Phenotypes of Hepatocyte-Derived Mouse Liver Tumors.Semantic proximity Read ↗

Role of YAP1 Signaling in Biliary Development, Repair, and DiseaseSemantic proximity Read ↗

Suppressor of hepatocellular carcinoma RASSF1A activates autophagy initiation and maturationSemantic proximity Read ↗

Tetraspanin 5 (TSPAN5), a Novel Gatekeeper of the Tumor Suppressor DLC1 and Myocardin-Related Transcription Factors (MRTFs), Controls HCC Growth and SenescenceSemantic proximity Read ↗

Complex roles of Hippo-YAP/TAZ signaling in hepatocellular carcinomaSemantic proximity Read ↗

Depletion of TRRAP Induces p53‐Independent Senescence in Liver Cancer by Down‐Regulating Mitotic GenesSemantic proximity Read ↗

Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liverSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.