Mechanism of tumor-suppressive cell competition in flies.

Abstract excerpt

Oncogenic mutations often trigger antitumor cellular response such as induction of apoptosis or cellular senescence. Studies in the last decade have identified the presence of the third guardian against mutation-induced tumorigenesis, namely "cell competition." Cell competition is a context-dependent cell elimination whereby cells with higher fitness eliminate neighboring cells with lower fitness by inducing cell...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Communication
• Share to Drosophila
• Share to Epithelial Cells